Nadolol
CAS No. : 42200-33-9
(Synonyms: SQ-11725)
| Size | Price | Stock |
|---|---|---|
| 25mg | $50 | In-stock |
| 50mg | $80 | In-stock |
| 100mg | $120 | In-stock |
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| Cat. No. : | HY-B0804 |
| M.Wt: | 309.41 |
| Formula: | C17H27NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research[1][2][3]. In Vitro: In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM[2]. In Vivo: In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress[3].
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