AK-7
CAS No. : 420831-40-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16691 |
| M.Wt: | 437.35 |
| Formula: | C19H21BrN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM. IC50 & Target: IC50: 15.5 μM (SIRT2)[1] In Vitro: AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons[1]. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures[3]. In Vivo: AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice[1]. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice[2].
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