Amorphigenin
CAS No. : 4208-09-7
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| Cat. No. : | HY-116640 |
| M.Wt: | 410.42 |
| Formula: | C23H22O7 |
| Purity: | >98 % |
| Solubility: |
Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders[1][2].
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