(S)-(-)-Propranolol (hydrochloride)
CAS No. : 4199-10-4
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| Cat. No. : | HY-B0573A |
| M.Wt: | 295.81 |
| Formula: | C16H22ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : ≥ 10 mg/mL |
(S)-(-)-Propranolol hydrochloride is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol hydrochloride produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol hydrochloride can be used in research related to hypertension, myocardial infarction, and pain[1][2].
In Vitro:(S)-(-)-Propranolol hydrochloride can be synthesized from D-Sorbitol (HY-B0400)[1].
(S)-(-)-Propranolol hydrochloride is the active isomer of Propranolol (HY-B0573B), a non-selective and blood-brain barrier-permeable β-adrenergic receptor antagonist[1][2].
In Vivo:(S)-(-)-Propranolol hydrochloride (S-PRO) (1-30 mg/kg; 60 min after administration) produces dose-dependent antinociceptive effects in the formalin-induced inflammatory pain mouse model[2].
(S)-(-)-Propranolol hydrochloride (30-60 mg/kg; 60 min after administration) impairs motor coordination and induces ataxia in mice in the rotarod test, with an ataxia ED50 = 22.2 mg/kg[2].
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