8-Chloro-cAMP
CAS No. : 41941-56-4
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| Cat. No. : | HY-123396 |
| M.Wt: | 363.65 |
| Formula: | C10H11ClN5O6P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1]. In Vitro: 8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1]. In Vivo: In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1].
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