Lenaldekar
CAS No. : 418800-15-4
(Synonyms: LDK)
| Size | Price | Stock |
|---|---|---|
| 1mg | $215 | Get quote |
| 5mg | $481 | Get quote |
| 10mg | $712 | Get quote |
| 25mg | $1133 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-121662 |
| M.Wt: | 286.33 |
| Formula: | C18H14N4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research[1][2].
In Vitro:Lenaldekar (4 days) inhibits CD3+ T cell proliferation in a dose-dependent manner with an IC50 of 3 μM[1].
Lenaldekar (3 μM, 4 days) reduces a memory T cell response to influenza antigen H3[1].
Lenaldekar (48 h) shows cytotoxicity in Jurkat T-ALL cell, with IC50s of 0.8 μM, and induces apoptosis (1 μM)[2].
In Vivo:Lenaldekar (40 mg/kg per day, i.p.) inhibits experimental autoimmune encephalomyelitis (EAE) relapse in mice sensitized with the encephalitogenic PLP139-151 peptide[1].
Lenaldekar (16 mg/kg, i.p., twice daily) inhibits tumor progession in a mouse xenograft model of T-cell acute lymphoblastic leukemia (T-ALL)[2].
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