Tricyclazole
CAS No. : 41814-78-2
| Size | Price | Stock |
|---|---|---|
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| Cat. No. : | HY-B0848 |
| M.Wt: | 189.24 |
| Formula: | C9H7N3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Tricyclazole is a pentaketone melanin biosynthesis inhibitor and a unique fungicide for controlling rice blast. Tricyclazole alters the structure and function of fungal cell walls, reduces fungal pathogenicity and penetration, and causes dose-dependent liver damage in animals[1][2][3][4][5].
IC50 & Target:Pentaketide-derived melanin biosynthesis[1]
In Vitro:Tricyclazole (16 μg/mL) causes morphological changes in Fonsecaea pedrosoi conidia and sclerotic cells[1].
Tricyclazole (0.1-10 μg/mL; 24-48 h) inhibits melanization of Pyriculariaoryzae appressoria, prevents penetration of epidermal cell walls and Formvar membranes, and increases permeability of appressorial walls to solutes[2].
In Vivo:Tricyclazole (5-15 mg/kg; i.p.; 5 days/week for 2 weeks) causes dose-dependent hepatic damage in mice, including altered liver enzyme levels and histopathological changes[3].
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