Catharanthine (Tartrate)
CAS No. : 4168-17-6
(Synonyms: (+)-3,4-Didehydrocoronaridine (Tartrate))
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| Cat. No. : | HY-N0252A |
| M.Wt: | 486.51 |
| Formula: | C25H30N2O8 |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic;warming;adjust pH to 3 with HCl;heat to 60°C);DMSO : 100 mg/mL (ultrasonic) |
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Tartrate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity[1][2].
In Vivo:Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) Tartrate evokes dose-dependent reductions in both BP and HR[1].
Catharanthine (40 mg/kg; ip; single dose) Tartrate with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h[1].
Catharanthine (20 mg/kg; ip; for 14 consecutive days) Tartrate increases swimming time and decreases immobility time at D7 or D14 in mice[1].
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