(-)-Pinoresinol 4-O-glucoside

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease^[1][2]. IC50 & Target:IC₅₀: 48.13 µM (α-Glucosidase)^[1] In Vitro:(-)-Pinoresinol 4-O-glucoside (0, 10, 30 µM; 24 h) increases cell migration during the differentiation of pre-osteoblasts in osteogenic supplement medium (OS) containing 50 μg/mL^[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 7 days) increases the early differentiation and increases mineralized nodule formation during differentiation of pre-Osteoblasts^[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases the expressio of BMP2, ALP, OCN mRNA levels in pre-osteoblasts^[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases protein level of BMP2, p-Smad1/5/8, RUNX2^[1]. In Vivo:(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice^[2].