Acid Red 94 lactone

Acid Red 94 lactone, a synthetic fluorescein derivative, is a deep red dye primarily composed of 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo fluorescein. It is widely used as an ophthalmic diagnostic agent to detect dry or damaged cells on the ocular surface. Acid Red 94 lactone exhibits antitumor activity and can inhibit Friend Leukemia Virus (FLV) infection through photodynamic action. Acid Red 94 lactone can inhibit Aβ aggregation through light irradiation. Acid Red 94 lactone holds potential for use in cancer, viral infections, and neurodegenerative disease research^{[1][2][3][4][5][6]}. In Vitro:Acid Red 94 lactone (300 µM, 48 h) exerts toxic effects on MCF-7 cells by inducing apoptosis^[3].
Acid Red 94 lactone (5 µM, under light irradiation, 24 h) inhibits Aβ aggregation, likely by binding to Ab42 and preventing its conformational transition^[4].
In Vivo:Acid Red 94 lactone (50 µL PV-10 (10% Rose Bengal solution), IL, once a week for 14 weeks) induced tumor-specific immune responses and reduced the number of lung metastases in the B16 melanoma mouse model^[5].
Acid Red 94 lactone (7-200 µg, i.p., single dose) inhibits FLV infection via photodynamic action^[6].