RI-1
CAS No. : 415713-60-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $130 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-15317 |
| M.Wt: | 361.61 |
| Formula: | C14H11Cl3N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells[1].
IC50 & Target: IC50: 5-30 μM (RAD51)[1]
In Vitro: RI-1 (1-50 µM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells[1].
RI-1 (5-20 µM; 30 min) inhibits HsRAD51 in a concentration-dependent manner[1].
RI-1 (20 µM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts[1].
RI-1 (15-25 µM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy[1].
In Vivo: RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice[2].
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