Bruceantin
CAS No. : 41451-75-6
(Synonyms: (-)-Bruceantin; NCI165563; NSC165563)
| Size | Price | Stock |
|---|---|---|
| 1mg | $132 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
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| Cat. No. : | HY-N0840 |
| M.Wt: | 548.58 |
| Formula: | C28H36O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities[1][2][3].
In Vitro:Bruceantin (2.5-40 ng/mL, 24 h) downregulates the expression of c-Myc in cell RPMI 8226, induces a decrease in mitochondrial membrane potential, leads to the release of cytochrome c, activates caspase-3/7, and induces apoptosis in cells RPMI 8226, U266 and H929 with IC50s of 13, 49 and 115 nM, respectively[1].
Bruceantin (0.1-1 μg/mL, 4-5 days) exhibits anti-amoebic activity, inhibits Entamoeba histolytica with an IC50 of 0.018 μg/mL[3].
In Vivo:Bruceantin (1.25-12 mg/kg, ip, every 3 days for 40 days) exhibits antitumor effect in mouse RPMI 8226 xenograft models[1].
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