ODQ
CAS No. : 41443-28-1
| Size | Price | Stock |
|---|---|---|
| 10mg | $132 | In-stock |
| 25mg | $204 | In-stock |
| 50mg | $308 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-101255 |
| M.Wt: | 187.16 |
| Formula: | C9H5N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1]. In Vitro: At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[1]. In Vivo: ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[2].
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