Stachydrine (hydrochloride)


CAS No. : 4136-37-2

4136-37-2
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Cat. No. : HY-N0738
M.Wt: 179.64
Formula: C7H14ClNO2
Purity: >98 %
Solubility: H2O : 100 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic)
Introduction of 4136-37-2 :

Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases[2]. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities[1]. IC50 & Target:NF-κB[1] In Vitro: Intervention of Stachydrine significantly suppresses the level of p-IκB (ser32) protein in the cytosol and NF-κB (p65) protein in the nucleus (P<0.05)[1].
Treatment with Stachydrine hydrochloride (50 μM, 200 μM, 500 μM and 1000 μM) noticeably inhibited MCF-7 and T47D cell proliferation in dose- and time-dependent manner[2].
High concentrations (500 μM and 1000 μM) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle, suggesting that Stachydrine hydrochloride could cause cell cycle arrest[2].

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