BAM(8-22)
CAS No. : 412961-36-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $250 | In-stock |
| 5mg | $560 | In-stock |
| 10mg | $850 | In-stock |
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| Cat. No. : | HY-P1241 |
| M.Wt: | 1971.20 |
| Formula: | C91H127N25O23S |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
BAM(8-22), a proteolytically cleaved product of proenkephalin A and sensory neuron-specific receptor (SNSR) agonist, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM(8-22) induces scratching in mice in an Mrgpr-dependent manner. In addition, BAM(8-22) has an analgesic effect and can also inhibit the activation of microglia[1][2][3][4].
In Vitro: BAM(8 - 22) (0.1-10 nM) can increase the level of miR-184, reduce the expression of Iba-1 and inflammatory cytokines in LPS (HY-D1056)-treated BV-2 cells[1].
In Vivo: BAM(8 - 22) (intradermal injection; 50 μL; 1 mM; single dose) can cause intense scratching behavior in WT mice, but the scratching behavior is significantly reduced in Mrgpr-clusterΔ−/− mutant mice[2].
BAM(8 - 22) (intrathecal injection; 10 μL; 3-30 nmol; single dose) has an ameliorating effect in the rat pain model[3].
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