Sirtinol
CAS No. : 410536-97-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $73 | In-stock |
| 10mg | $112 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $449 | In-stock |
| 100mg | $766 | In-stock |
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| Cat. No. : | HY-13515 |
| M.Wt: | 394.47 |
| Formula: | C26H22N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively[1][2][3][4]. IC50 & Target: IC50: 48 μM (ySir2), 57.7 μM (hSIRT2), 131 μM (hSIRT1)[4] In Vitro: Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC50 values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level[1]. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1[2]. In Vivo: Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury[3].
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