DOV-102,677
CAS No. : 410074-75-8
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| Cat. No. : | HY-18332B |
| M.Wt: | 228.12 |
| Formula: | C11H11Cl2N |
| Purity: | >98 % |
| Solubility: |
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC50 = 129 nM; Ki = 222 nM), norepinephrine (NET) (IC50 = 103 nM; Ki = 1030 nM), and serotonin (SERT) (IC50 = 133 nM; Ki = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression[1].
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