YM-1
CAS No. : 409086-68-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18399 |
| M.Wt: | 417.98 |
| Formula: | C20H20ClN3OS2 |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 50 mg/mL (ultrasonic) |
YM-1 is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins[1][2]. In Vitro:YM-1 promotes Hsp70-dependent steps in nNOS maturation and partially blocks formation of the ATP-bound form[1]. YM-1 (0-200 μM) activates the binding of Hsp70 to its unfolded substrate[1]. YM-1 (0.001-1000 μM) converts Hsp70 to its tight-affinity conformation and shows binding efficacy to Hsp70 with an IC50 value of 8.2 μM[1]. YM-1 (0, 0.1, 0.5 and 1 μM; 24 hours) promotes nNOS ubiquitination[1]. YM-1 (5 and 10 μM; 24 and 48 hours) induces cell death of HeLa cells and growth arrest of hTERT-RPE1 cells[2]. YM-1 (10 μM; 48 hours) up-regulates p53 and p21 proteins and down-regulates FoxM1 and survivin[2]. In Vivo:YM-1 (1 mM; oral administration, for 7 days) rescues polyQ toxicity in Drosophila by activating Hsp70[1].
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