PD146176
CAS No. : 4079-26-9
(Synonyms: NSC168807)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $207 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $580 | In-stock |
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| Cat. No. : | HY-103157 |
| M.Wt: | 237.32 |
| Formula: | C15H11NS |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3].
IC50 & Target: Ki: 197 nM (Rabbit reticulocyte 15-LO)[1]
IC50: 0.54 μM[2]
In Vitro: In intact IC21 cells transfected with human 15-LO, PD146176 inhibits 13-HODE production with an IC50 of 0.81 μM[2].
In Vivo: PD146176 (80 mg/kg; Chowing; 12 weeks) reverses cognitive impairment, brain amyloidosis, and Tau pathology by stimulating autophagy in aged triple transgenic mice[3].
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