CaCCinh-A01
CAS No. : 407587-33-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $105 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $640 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100611 |
| M.Wt: | 347.43 |
| Formula: | C18H21NO4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively. IC50 & Target: IC50: 2.1 μM (TMEM16A)[1], 10 μM (CaCC)[2] In Vitro: 30 μM CaCCinh-A01 and 100 μM tannic acid strongly inhibit CaCC current following ATP stimulation[1]. Calcium-dependent chloride current is reduced by 38±14, 66±10, and 91±1% by 0.1, 1, and 10 μM CaCCinh-A01, respectively. ATP-induced short-circuit currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively[2]. In Vivo: CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice[3].
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