RX 67668
CAS No. : 40709-76-0
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| Cat. No. : | HY-124047 |
| M.Wt: | 265.82 |
| Formula: | C16H24ClN |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue[1][2].
IC50 & Target: IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase)[1]
In Vivo: RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value[1].
Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade[1].
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