Sulisobenzone

Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress^[1]. In Vitro:Sulisobenzone (3.1-98.7 mg/L) downregulates thyroid hormone-regulated genes in rat pituitary cell lines^[1].
Sulisobenzone (76 mg/L) induces oxidative damage and reduces viability in the microalga Chlamydomonas reinhardtii, increasing ROS levels by up to 1.5-fold and decreasing growth rate, membrane potentials, metabolic activity, and autofluorescence^[1]. In Vivo:Sulisobenzone (10 μg/L; waterborne; 22 days) disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function in juvenile gilt-head sea bream, as evidenced by 371 differentially expressed liver genes and widespread modulation of plasma and liver metabolites across key metabolic pathways^[1].