BTO-1
CAS No. : 40647-02-7
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| Cat. No. : | HY-112395 |
| M.Wt: | 264.22 |
| Formula: | C9H4N4O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications[1][2]. IC50 & Target: Plk[1][2] In Vitro: BTO-1 (50 μM; 4 hours; U20S cells) results in monopolar spindles in a comparable fraction of mitotic cells. BTO-1(20 μM; 1 hour; PTK cells) shows a dose-dependent reduction in phospho-Cdc25C. BTO-1(25 μM; 1 hour; PTK cells) shows about 20 % reduction in H3 phosphorylation compared to control cells. BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring[1][2].
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