Cirazoline (hydrochloride)


CAS No. : 40600-13-3

(Synonyms: LD 3098 (hydrochloride))

40600-13-3
Price and Availability of CAS No. : 40600-13-3
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Cat. No. : HY-101300
M.Wt: 252.74
Formula: C13H17ClN2O
Purity: >98 %
Solubility: H2O : 33.33 mg/mL (ultrasonic)
Introduction of 40600-13-3 :

Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1]. In Vitro: Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin-induced GIC death[1].
In Vivo: Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1].

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