(±)-Carnitine


CAS No. : 406-76-8

(Synonyms: DL-Carnitine; DL-Levocarnitine)

406-76-8
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Cat. No. : HY-B0399A
M.Wt: 161.20
Formula: C7H15NO3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 406-76-8 :

(±)-Carnitine (DL-Carnitine) is an orally effective racemic mixture of L-Carnitine (HY-B0399) and D-Carnitine. (±)-Carnitine elevates the mitochondrial NAD+/NADH ratio in the presence of 1,3-butanediol (HY-77490A). (±)-Carnitine does not increase glucose and urea production from L-glutamine, but stimulates propionate gluconeogenesis in rat renal cortical slices, and significantly reduces hepatic ketone body levels in rats fed a diet containing 30% high fat plus 20% 1,3-butanediol[1][2][3]. In Vitro:(±)-Carnitine (1 mM) stimulates the rate of propionate gluconeogenesis in rat renal cortical slices by 3- to 5-fold[1].
In Vivo:(±)-Carnitine (0.2%; administered orally via diet; ad libitum access; 43 days) exerts no effect on hepatic metabolic parameters in rats fed a 30% high-fat diet alone, but significantly reduces hepatic ketone body levels and restores normal mitochondrial redox status in rats fed a diet containing 30% high-fat plus 20% 1,3-butanediol[3].

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