Ethyl ferulate

Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress^[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity^[2]. In Vitro:Ethyl ferulate (1-50 μM, 6 or 24 h) increases HO activity, HO-1 mRNA, and protein expression in astrocytes and hippocampal neurons^[1].
Ethyl ferulate (5 μM, 12 h) protects rat hippocampal neurons from GOX-induced cell death by induction of HO-1^[1].
Ethyl ferulate (10-50 μM, 24 h) protects primary neuronal cells against Aβ-peptide (1–42)-induced cytotoxicity, formation of 3-NT, ROS accumulation, and lipid peroxidation^[2].
Ethyl ferulate (20-160 µM, 24 h) protects RPE cells from CoCl₂ (150 µM) induced reduction in cell viability^[5].
Ethyl ferulate (40 µM, 24 h) inhibits CoCl₂-induced VEGFA expression by activating the Nrf-2 pathway and reducing ROS generation in RPE cells^[5].
In Vivo:Ethyl ferulate (15-50 mg/kg, i.p., twice a day for 5 days) inhibits LPS-induced acute lung injury in mice^[3][4].
Ethyl ferulate (0.05-0.2 μg, intravitreal administration, 1 µl/eye) inhibits retinal neovascularization in the oxygen-induced retinopathy mice model^[5].