Yatein
CAS No. : 40456-50-6
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| 5mg | $700 | Get quote |
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| Cat. No. : | HY-N1060 |
| M.Wt: | 400.42 |
| Formula: | C22H24O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression[2].
IC50 & Target: HSV-1[2]
In Vitro: Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization[3].
In Vivo: Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model[3].
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