AMA-37
CAS No. : 404009-46-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $490 | In-stock |
| 10mg | $790 | In-stock |
| 25mg | $1580 | In-stock |
| 50mg | $2550 | In-stock |
| 100mg | $4090 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100706 |
| M.Wt: | 283.32 |
| Formula: | C17H17NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2].
IC50 & Target: IC50: 0.27 μM (DNA-PK)[1].
In Vitro: AMA-37 inhbits PI3K poorly[2].
AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (ρ < 0.05)[3].
Inhibition of DNA-PK with AMA37 leads to radiosensitization[3].
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