IC 86621
CAS No. : 404009-40-1
| Size | Price | Stock |
|---|---|---|
| 100mg | $582 | Get quote |
| 250mg | $1090 | Get quote |
| 1g | $2105 | Get quote |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-100707 |
| M.Wt: | 221.26 |
| Formula: | C12H15NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].
IC50 & Target: IC50: 120 nM (DNA-PK)[1]
In Vitro: IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12[1].
IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis[2].
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