Pamidronic acid
CAS No. : 40391-99-9
| Size | Price | Stock |
|---|---|---|
| 25mg | $38 | In-stock |
| 50mg | $60 | In-stock |
| 100mg | $96 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B0012 |
| M.Wt: | 235.07 |
| Formula: | C3H11NO7P2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL;H2O : 5 mg/mL (ultrasonic;warming;heat to 80°C) |
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
In Vitro:Pamidronic acid (0.001-1000 µM, 72 h) inhibits the cell viability of osteosarcoma cells POS, HMPOS and COS31, exhibits no cytotoxicity to fibroblasts[1].
In Vivo:Pamidronic acid (3 mg/kg, ear vein injection, once monthly for 14 weeks) improves the bone structure, alleviates the degenerative changes of cartilage, exhibits protective effect against osteoarthritis in rabbit models[3].
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