PF-03049423


CAS No. : 402955-58-2

402955-58-2
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Cat. No. : HY-10679A
M.Wt: 1000.00
Formula: C24H32N6O4.xHCl
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 402955-58-2 :

PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke[1]. In Vivo: PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion[1].
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].

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