FTY720 (S)-Phosphate
CAS No. : 402616-26-6
(Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)
| Size | Price | Stock |
|---|---|---|
| 5mg | $520 | In-stock |
| 10mg | $830 | In-stock |
| 25mg | $1680 | In-stock |
| 50mg | $2690 | In-stock |
| 100mg | $4300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15382 |
| M.Wt: | 387.45 |
| Formula: | C19H34NO5P |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming;heat to 80°C);H2O : < 0.1 mg/mL |
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. IC50 & Target:S1PR1[1] In Vitro:FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1]. In Vivo:FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].
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