Fingolimod phosphate
CAS No. : 402615-91-2
(Synonyms: FTY720 phosphate)
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $460 | In-stock |
| 10mg | $780 | In-stock |
| 25mg | $1560 | In-stock |
| 50mg | $2340 | In-stock |
| 100mg | $4480 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15381 |
| M.Wt: | 387.45 |
| Formula: | C19H34NO5P |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases[1].
In Vitro: Fingolimod phosphate prevents lymphocytes from moving out of the lymphoid organs and inhibits autoreactive lymphocytes from infiltrating the central nervous system[1].
Fingolimod phosphate (0, 1, 10, 100 nM) binds S1P1 receptors to downregulate activated microglial production of such pro-inflammatory cytokines as tumor necrosis factor-a, interleukin-1β, and interleukin-6[1].
Fingolimod phosphate (0, 1, 10, 100 nM) also upregulates microglial production of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor[1].
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