H-Hyp-OMe (hydrochloride)
CAS No. : 40216-83-9
| Size | Price | Stock |
|---|---|---|
| 10g | $6 | In-stock |
| 25g | $8 | In-stock |
| 100g | $19 | In-stock |
| 500g | $68 | In-stock |
| 1000g | $136 | In-stock |
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| Cat. No. : | HY-76043 |
| M.Wt: | 181.62 |
| Formula: | C6H12ClNO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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