AS057278
CAS No. : 402-61-9
| Size | Price | Stock |
|---|---|---|
| 5g | $11 | In-stock |
| 10g | $18 | In-stock |
| 25g | $35 | In-stock |
| 100g | $125 | In-stock |
| 500g | $624 | In-stock |
| 1 kg | Get quote | |
| 2 kg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-33009 |
| M.Wt: | 126.11 |
| Formula: | C5H6N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1].
IC50 & Target:IC50: 0.91 μM (DAAO)[1]
In Vivo:AS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes phencyclidine (PCP)-induced prepulse inhibition[1].
AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects[1].
Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats[1].
| IV (10 mg/kg) | PO (10 mg/kg) | |
| C0 (ng/mL) | 100,557.3 | |
| Cmax (ng/mL) | 73,559.8 | 8088.8 |
| tmax (h) | 0.083 | 1 |
| CZ (ng/mL) | 26.8 | 40.5 |
| tZ (h) | 24 | 24 |
| AUCZ (ng/mL·h) | 45,596.2 | 18,254.4 |
| λZ (h^-1) | 0.124 | 0.096 |
| AUC (ng/mL·h) | 45,810.9 | 18,649.9 |
| VZ (L/kg) | 1.76 | |
| VSS (L/kg) | 0.24 | |
| CL (L/kg/h) | 0.22 | |
| MRT (h) | 1.087 | |
| F | 0.407 |
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- AS057278
- Cat. No.:
- HY-33009
- Quantity:
Your information is safe with us.