Carotegrast
CAS No. : 401904-75-4
(Synonyms: HCA2969)
Price and Availability of
CAS No. : 401904-75-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-14857 |
| M.Wt: | 555.41 |
| Formula: | C27H24Cl2N4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Introduction of
401904-75-4
:
Carotegrast (HCA2969) is an orally active α4 integrin inhibitor with anti-inflammatory activity. Carotegrast can be used in the research of inflammation-related diseases, such as ulcerative colitis[1][2].
IC50 & Target:α4 integrin receptor[1]
In Vivo:Pharmacokinetic Analysis in cynomolgus monkeys treated with Vehicle or Rifampin (HY-B0272)[2]
| / | Route | Dose (mg/kg) | T1/2 (h) | Plasma CL (mL/min/kg) | V (mL/kg) | Cmax (nM) | AUClast (h*nM) |
| Vehicle | i.v. | 0.5 | 0.82 | 6.91 | 114 | 4717 | 2625 | Rifampin | i.v. | 0.5 | 1.49 | 0.69 | 45 | 22806 | 23770 |