NCX 1000
CAS No. : 401519-96-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $262 | In-stock |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
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| Cat. No. : | HY-U00023 |
| M.Wt: | 685.84 |
| Formula: | C38H55NO10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NCX 1000 is a liver-specific NO donor compound derived from ursodeoxycholic acid (UDCA). In Vivo: NCX-1000 (15 mg/kg, p.o.) prevents ascite formation, reduces collagen deposition in CCl4-treated rats. NCX-1000 administration almost completely reverts portal hypertension induced by CCl4, and reduces portal pressure in cirrhotic rats. NCX-1000 reverts HSC contraction induced by FCS, and also inhibits MCP-1 release from HSCs stimulated with TNF-α and IFN-γ[1]. NCX-1000 (28 mg/kg, p.o.) decreases portal pressure without affecting mean arterial pressure and heart rate in rats. NCX-1000 also reduces vasoconstriction by 60% caused by 30 μM NE in rats. Administration of NCX-1000 to BDL and sham operated rats results in a similar increase of nitrite/nitrate and cGMP concentrations in the liver[2].
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