Aviptadil
CAS No. : 40077-57-4
(Synonyms: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine))
| Size | Price | Stock |
|---|---|---|
| 1mg | $144 | In-stock |
| 5mg | $300 | In-stock |
| 10mg | $420 | In-stock |
| 50mg | $780 | In-stock |
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| Cat. No. : | HY-P0012 |
| M.Wt: | 3325.80 |
| Formula: | C147H238N44O42S |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al[1][2][3][4][5].
In Vivo: Aviptadil (500 μg/kg; Intravenous injection; Every other day; Three weeks) completely prevented and significantly reversed Monocrotaline (MCT) (HY-N0750) -induced Pulmonary Arterial Hypertension in Sprague Dawley rat models (PAH)). Aviptadil is synergistic with Bosentan (HY-A0013)[3].
Aviptadil (150 μg/kg/d; Intraperitoneal pump; 2.5 μl/h; 4 weeks) can eliminate bronchial hyperreactivity (BHR) in Sprague-Dawley rats, with a characteristic of bronchiectasis[3].
Aviptadil (0.1, 3 μg/kg; Intravenous injection (i.v.)) can improve reperfusion injury in living rat lung transplantation models[5].
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