DOPE
CAS No. : 4004-05-1
(Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)
| Size | Price | Stock |
|---|---|---|
| 100mg | $59 | In-stock |
| 250mg | $101 | In-stock |
| 1g | $373 | In-stock |
| 5g | $1067 | In-stock |
| 10g | $1813 | In-stock |
| 25g | $3730 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-112005 |
| M.Wt: | 744.03 |
| Formula: | C41H78NO8P |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1]. IC50 & Target:IC50: helper lipid for liposome[1] In Vitro: In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].
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