(rac)-Methyl jasmonate

(rac)-Methyl jasmonate is the racemate of Methyl jasmonate (HY-135663). Methyl jasmonate is a phytohormone that regulates the defense response of plants under biotic and biotic stress through jasmonate signaling pathway. Methyl jasmonate inhibits the activation of NF-κB signaling pathway. Methyl jasmonate can promote the mitochondrial ROS production, but also scavenges free radicals and reduces the oxidative stress. Methyl jasmonate exhibits anti-inflammatory, antitumor, anticonvulsant, antinociceptive and sedative activities^{[1][2][3][4][5][6]}. In Vitro:Methyl jasmonate (1-2 mM, 24 h-14 days) suppresses the expression of PCNA, XIAP and survivin, inhibits the cell viability (IC₅₀s for SK-N-SH and BE(2)-C are 1.39 mM and 1.35 mM) and colony formation of human neuroblastoma cells SK-N-SH and BE(2)-C, induces cell arrest at G0/G1 phase, and induces apoptosis in SK-N-SH and BE(2)-C cells^[3].
In Vivo:Methyl jasmonate (75-300 mg/kg, po, once daily for 18 days) reduce inflammatory response and oxidative stress in Freund’s adjuvant (HY-153808)-induced rats arthritis models^[1].
Methyl jasmonate (10-40 mg/kg, ip, once daily for 7 days) inhibits the AChE activity in mice brains, enhances the spatial working memory of mice, and reverses Scopolamine (HY-N0296)-induced memory impairment in Swiss mouse models^[5].
Methyl jasmonate (10-50 mg/kg, ip, single dose) exhibits anti-inflammatory and analgesic activities in Acetic acid (HY-Y0319)-induced mouse writhing models^[6].