2'-Deoxycytidine (hydrochloride)

2'-Deoxycytidine hydrochloride is an orally effective nucleic acid biosynthesis enzyme inhibitor. 2'-Deoxycytidine hydrochloride competes with nucleic acid biosynthesis enzymes and nucleoside transporters, thereby reducing the toxicity of cytarabine. 2'-Deoxycytidine (hydrochloride) can be used in the research of L1210 lymphoblastic leukemia^[1]. In Vivo:2'-Deoxycytidine (hydrochloride) (40-480 mg/kg; p.o.; three/four times daily; 4-18 days) co-administration completely prevents araC-induced lethal toxicity in normal mice, partially or fully protects most hematopoietic cell lineages except bone marrow lymphocytes, and normalizes araC-induced cellular immune suppression without reversing araC's humoral immune suppression^[1].
2'-Deoxycytidine (hydrochloride) (360-480 mg/kg; p.o.; three/four times daily; days 5-26) co-administration prevents araC-induced lethal toxicity in leukemia-bearing mice, maintains or enhances araC's antitumor efficacy against L1210 lymphoblastic leukemia, and reduces araC's antitumor effect against non-lymphoid Graffi MG and Rauscher ER leukemias^[1].