5-Fluoroindole

5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC₅₀ of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker^[1][2][3]. In Vitro:5-Fluoroindole (4.7-29.1 μM) inhibits the growth of pansensitive Mycobacterium tuberculosis (Mtb) H37Rv strain and drug-resistant clinical isolates^[1].
5-Fluoroindole has high metabolic stability (Cl_int 9.0 mL/min/kg) in rat liver microsomes^[1].
5-Fluoroindole exhibits significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa), with an EC₅₀ of 15.34 μg/mL^[2].
In Vivo:5-Fluoroindole (200 μmol/kg; p.o.) hydrochloride reduces the Mtb burden in the lungs of mice infected with Mtb H37Rv without toxicity^[1].