Clorobiocin
CAS No. : 39868-96-7
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| Cat. No. : | HY-123515 |
| M.Wt: | 697.13 |
| Formula: | C35H37ClN2O11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Clorobiocin is an antibacterial agent with an IC50 of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections[1][2].
In Vitro:Combination treatment with clorobiocin (12.5 μM; overnight) and LL-37 (HY-P4744) exhibits synergistic antibacterial activity against Acinetobacter baumannii AB5075, with a fractional inhibitory concentration (FIC) value of 0.5[1].
Clorobiocin (14 μM; 24-48 h) inhibits the growth of Escherichia coli J53 in vitro with a bacteriostatic concentration of 14 μM, and the concentration required for it to inhibit bacterial growth is 67-fold higher than that required for inhibiting DNA gyrase[2].
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