PHA-680626
CAS No. : 398493-74-8
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| Cat. No. : | HY-125090 |
| M.Wt: | 450.56 |
| Formula: | C23H26N6O2S |
| Purity: | >98 % |
| Solubility: |
PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells[1].
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