Penciclovir
CAS No. : 39809-25-1
(Synonyms: BRL 39123; VSA 671)
| Size | Price | Stock |
|---|---|---|
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| 100mg | $40 | In-stock |
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| Cat. No. : | HY-17424 |
| M.Wt: | 253.26 |
| Formula: | C10H15N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2].
IC50 & Target: IC50: 0.04-1.8 μg/mL (HSV-1), 0.06-4.4 μg/mL (HSV-2), 1.6-8 μg/mL (VZV), 1.5-3.1 μg/mL (EBV), 51 μg/mL (HCMV)[1]
In Vitro: Penciclovir (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir (0-100 µg/ml) shows no-toxic to uninfected human cells[1].
In Vivo: Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2].
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