Triamterene
CAS No. : 396-01-0
| Size | Price | Stock |
|---|---|---|
| 100mg | $25 | In-stock |
| 500mg | $35 | In-stock |
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| Cat. No. : | HY-B0575 |
| M.Wt: | 253.26 |
| Formula: | C12H11N7 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor[1][2].
In Vitro:Triamterene shows cytotoxicity against HCT116 and CT26 cells, with IC50 values of 31.30 and 24.45 μM[5].
Triamterene (100 and 200 µM, 2 h) increases lysosomal rupture, decreases integrity of lysosomes, and activates lysophagy in HepG2 cells[6].
Triamterene (10-100 µM) inhibits the delayed rectifier potassium current in guinea pig ventricular myocytes[7].
In Vivo:Triamterene (10-40 mg/kg/day, p.o., 5 days) shows anticonvulsant effects in seizure models of mice induced by intravenous Pentylenetetrazole (PTZ) (0.5%, 1 mL/min), intraperitoneal PTZ (85 mg/kg) and maximal electroshock seizure (MES)[3].
Triamterene (25 mg/kg) reduces urinary magnesium excretion in conscious saline-loaded rats[4].
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