Imrecoxib


CAS No. : 395683-14-4

(Synonyms: BAP-909)

395683-14-4
Price and Availability of CAS No. : 395683-14-4
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Cat. No. : HY-114200
M.Wt: 369.49
Formula: C21H23NO3S
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 395683-14-4 :

Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect[1]. In Vitro: Imrecoxib (BAP-909) (0.1-10 µM; 24 hours) decreases COX-2 mRNA level induced by PMA+LPS at a dose dependent manner in U937 cells[1]. In Vivo: Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) inhibits carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours[1].
Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling and inhibits heat-inactivated BCG induced-inflammtory polyarthritis[1].

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