Nitrendipine

Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma^{[1][2][3][4][5][6][7][8][9][10][11]}. IC50 & Target:Calcium channel^[1] In Vitro: Nitrendipine (25-200 μM; 24-48 h) decreases the proliferation of murine neuroblastoma (N2a cells) in a concentration-dependent manner^[1]. In Vivo: Nitrendipine (50 mg/kg; i.p.) prevents the behavioural signs of ethanol withdrawal in mice^[2].
Nitrendipine (25-50 mg/kg; i.p.; once a day during the morphine treatment for chronic study, 1 h after the last dose of morphine for acute study) blocks some signs of Morphine withdrawal in mice, such as hair raising, sniffing, diarrhea and the number of jumps^[3].
Nitrendipine (1-10 mg/kg; i.p.; twice-daily) blocks the antinociceptive effects of chronic ethanol and prevents the hyperalgesia produced by ethanol withdrawal in rats^[4].
Nitrendipine (50 mg/kg; i.p.) strongly attenuates the lipid peroxidation (LPO) in the lung of mice and rabbits induced by Naphthalene (NAP)^[5].
Nitrendipine (10 mg/kg; p.o.; twice a day; 30 days) significantly reduces the right ventricular hypertrophy and pulmonary vascular changes caused by intermittent hypoxia in rats^[6].
Nitrendipine (5-10 mg/kg; via catheter of gastric fistula) shows a synergistic effect with Hydrochlorothiazide (HY-B0252) on reducing blood pressure and blood pressure variability in spontaneously hypertensive rats (SHR)^[7].
Nitrendipine (1000 ppm; p.o.; 3 weeks) can reduce blood pressure, improve glucose tolerance, and increase glucose uptake in the heart and skeletal muscle of spontaneously hypertensive rats^[8].