Fenpropathrin
CAS No. : 39515-41-8
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| Cat. No. : | HY-123178 |
| M.Wt: | 349.42 |
| Formula: | C22H23NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fenpropathrin is a synthetic pyrethroid insecticide in agriculture. Fenpropathrin may induces parkinsonian symptoms progressively[1].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Fenpropathrin can be used in animal modeling to create Parkinson's syndrome models. Fenpropathrin is lipophilic, allowing it to cross the blood-brain barrier, and it is characterized by rapid metabolic clearance in mammals[1].
Administration: 15 mg/kg, i.p. • 1 μL of 6 μg/μL Fenpropathrin solution, stereotaxical infusion • once daily for 60 days
(2) Half of the rats did not receive any treatment within 60 days after the last injection of Fenpropathrin, while the other half of the rats were euthanized 24 hours after the last Fenpropathrin treatment.
(3) For ST infusion, Fenpropathrin solution was injected into the right ventral tegmental area and substantia nigra pars compacta (SNc) at a flow rate of 0.2 μ L/min. After injection, the needle was left in place for 5 minutes to allow the drug to fully diffuse, and then the needle was slowly removed.
(4) Measure the levels of dopamine, DOPAC, and HVA in the striatum using HPLC.
(5) Slice the brain tissue into 15 μm thick sections using a low-temperature cryostat to analyze the immunoreactivity of DAT and VMAT2.
Behavioral observation: After 4 weeks of treatment, there was a decrease in movement activity, less climbing, reduced escape behavior, and slower movement.
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