Isoxsuprine
CAS No. : 395-28-8
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| Cat. No. : | HY-B1270A |
| M.Wt: | 301.38 |
| Formula: | C18H23NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Isoxsuprine is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
IC50 & Target:Ki: 13.65 μΜ (myometrial beta-adrenergic receptor), 3.48 μΜ (placcntal beta-adrenergic receptor)[1]
NMDA receptor[3]
In Vitro: Results show that Isoxsuprine inhibits CCID formation dose dependently (5 to 60 μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin)[2].
In Vivo: Total infarct volume in vehicle-treated animals is 279±25 mm3 compare to 137±18 mm3 in Isoxsuprine -treated animals[3].
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